Familial recurrence of congenital heart diseases

Familial Congenital Heart Disease

GENETIC imbalance, the result of aneuploidy or chromosomal structural rearrangements, is now recognized as a cause of anomalous embryogenesis. In general, the anomalies have been extensive and severe when the chromosomal abnormalities have affected segments lengthy enough to be detected by use of currently available techniques. The purposes of the present study were: (1) to determine the incide...

[Familial congenital heart disease].

Familial recurrence of congenital heart disease in patients with ostium secundum atrial septal defect.

AIMS Ostium secundum atrial septal defect (osASD) is one of the most common cardiac malformations. Few data are available on the familial recurrence of congenital heart disease (CHD), in particular, in a large group of patients with isolated osASD. The aim is to investigate the familial recurrence of CHD in up to third-degree relatives from a large sample of consecutively enrolled patients with...

Recurrence of Congenital Heart Disease in Cases with Familial Risk Screened Prenatally by Echocardiography

OBJECTIVES To evaluate the recurrence of congenital heart disease (CHD) in pregnant women with familial risk who had been referred for fetal echocardiography. MATERIAL AND METHODS 1634 pregnancies from 1483 women with familial history of CHD in one or more relatives were studied. Fetal cardiologic diagnosis was compared with postnatal findings at 6 months or at autopsy. RESULTS Total recurr...

Recurrence of congenital heart defects in families.

BACKGROUND Knowledge of the familial contribution to congenital heart diseases (CHD) on an individual and population level is sparse. We estimated an individual's risk of CHD given a family history of CHD, as well as the contribution of CHD family history to the total number of CHD cases in the population. METHODS AND RESULTS In a national cohort study, we linked all Danish residents to the N...